Immunotherapy: Your Immune System is Cancer's Biggest Enemy

There’s no doubt about it - our immune systems are powerful. We’ve all had moments where we don’t pay much attention to our immune systems because of lack of sleep or high stress and had to endure bouts of sneezing, coughing, or fever in the coming days. Some of us have taken extra steps to make sure our immune systems are as strong as possible and noticed how invincible it feels to go months without getting sick. Everyday function, brain power, and physical ability depend strongly on our body’s ability to fight off viruses and disease.

The power that our immune system provides in determining our health can even be utilized to fight cancer. Immunotherapy is a method of cancer treatment that helps to strengthen the immune system to be able to fight cancer cells better, as well as direct the immune system towards specific cancer cells.

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A large number of cells in our body aid in the immune system. White blood cells (lymphocytes) recognize foreign bodies such as viruses and fight them with antibodies, which are proteins that are sent out to bind to these foreign bodies. T cells are a specific type of white blood cell that search for, capture and destroys foreign bodies and infected cells.

Immunotherapy works with these cell types to focus in on cancer cells and kill as many as possible. There are many different methods of immunotherapy that enhance the immune system in a variety of ways.

Proteins called monoclonal antibodies (therapeutic antibodies) can be created in a laboratory and used for immunotherapy. These antibodies are introduced into the body to flag cancer cells so the immune system can more easily detect them.

Checkpoint inhibitors can be put into a patient’s bloodstream to disable proteins that stop the immune system from attacking cancer cells. These proteins attach to T cells, and can activate or deactivate the immune system when needed. Because cancer cells can pose as normal cells and pass a T cell checkpoint without any activation of the immune system, checkpoint inhibitors are used to make sure that T cells will be activated to help destroy cancer cells with each encounter.

Adoptive cell transfer is a form of therapy that can also help boost the function of T cells. In this method, T cells are taken from the body, and the cells that are most defensive are grown and multiplied in a lab and put back into the body intravenously.

Prints of Cancer and the Immune System

Through the technology that scientists now have available in labs, immunotherapy provides another option for cancer treatment which can give many patients more hope. Although this type of therapy has its own side effects, and sometimes has the potential to damage the body, it has been known to successfully treat some cancers when radiation or chemotherapy failed, and can also enhance the effectiveness of other methods of treatment when used in combination.

Overall, it has the potential to provide hope to many of millions of people around the world affected by cancer.

• livescience.com
• cancer.gov
• immunology.org
• pacificimmunology.com
• tcells.org

Origins of Modern Chemistry

How did we get from discovering fire to using nanotubes in labs?

The concept of atoms was first conceived in ancient Greece by a group of philosophers known as the atomists. In 330 BC, Aristotle opposed this theory. He was a proponent of the elemental theory, positing that all matter was composed of the elements earth, fire, water, and air. He even added an element, aether (or ether).

The elemental theory continued into the middle ages through the study of alchemy. Alchemists added sulfur, salt, and mercury to the list.

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of the History of Modern Chemistry

Finally, in 1661, Robert Boyle published the book "The Sceptical Chymist", presenting his hypothesis of particles in motion and asserting that only experiments using the "scientific method" could be considered true.

Another milestone in chemistry was the discovery of electrochemistry. Alessandro Volta invented the first battery in 1800, using piles of copper and zinc discs. They were separated by cloth soaked in brine. When wires were attached to the top and bottom, electricity flowed through the wires.

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Antoine-Laurent de Lavoisier established the Law of the Conservation of Mass, also called "Lavoisier's Law", in 1789. His book "Elementary Treatise of Chemistry" is considered the first modern chemistry textbook. It contained a list of elements, or substances that could not be broken down further, including oxygen, nitrogen, hydrogen, phosphorus, mercury, zinc, and sulfur.

Lavoisier, unfortunately, lost his head to the guillotine during the French Revolution, but not before beginning his own revolution in science and becoming the father of modern chemistry.

History of Flight: From Kites to Space Travel

There are over 100,000 airplane flights a day, with almost 10,000 planes in the air simultaneously. It's taken humanity thousands of years to get to this point, starting with the invention of the humble kite in China in 475 BC.

The popularity of kite flying in China began people thinking about making human flight a reality. Soaring through the air untethered to the ground. Before, it has been the realm of mythology, such as Icarus, Alexander the Great, and Pegasus.

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On the way, there were many failed attempts over the centuries. At first, many inventors tried to replicate the wings of birds, even using feathers or lightweight wood. But, a human's arm muscles are not like a bird's.

Leonardo DaVinci made over 100 drawings of his theories of flight and flying machines. None of which were built in his lifetime.

It took until 1783, Paris, France before man reached this goal. Jean-François Pilâtre de Rozier and François Laurent d'Arlandes flew in a balloon created by the Montgolfier brothers.

Balloon travel brought us blimps, zeppelins, and airships. Over time the hot air balloon was refined and morphed by inventors, eventually bringing us to gliders. This development brought us a big step closer to a true airplane. George Cayley designed version of a glider that use the movements of the human body to control it.

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Samuel Langley, who was the Smithsonian Institute Secretary came close to unmanned flight in 1891. He built a model called the Aerodrome, which was powered by a steam engine. It flew for 3/4 of a mile. But, when he scaled it up to fit a person, it never flew successfully. After one test flight over the Potomac River, a journalist said, " It slid into the water like a handful of mortar."

While Langley was concentrating on propulsion, the Wright Brothers, bicycle mechanics by trade, in Kitty Hawk, NC, were focus on balance. They did their research without the help of a large institution, looking into the history of flight so far, and building models and even a wind tunnel.

Finally, on December 17, 1903, Wilbur and Orville Wright successfully flew the first powered aircraft. Their plane flew 852 feet. In another 11 years, the first scheduled commercial flight took off, transporting people between St. Petersburg and Tampa, Florida.

Planes become critical during WWI. The Germans used airplanes such as the Fokker Eindecker as well as Zeppelins to drop bombs on the allies.

In 1927 Lindbergh completed the first solo nonstop flight across the Atlantic Ocean. Eventually, commercial air travel would become commonplace.

Today gigantic cargo planes with wingspans of 290 feet can carry 640 tons.

Humans are never satisfied, so we keep pushing flight further. First to land on the moon and who knows where we'll travel next.

Vaccines: How They Protect Us

Although vaccination has been a hot topic in recent news, the study of vaccination goes back to around 1,000 years ago. Early records of smallpox immunization, called variolation, can be dated back to 1000 CE in China.

Variolation was a practice that involved taking material (usually part of a scab) from a patient that was infected with smallpox and exposing a healthy individual to this material. The doctor would often insert the infected material underneath the healthy person’s skin to achieve proper exposure. The hope was that the healthy person would get sick, their immune system would successfully fight the virus, and they would then be immune to the disease once they recovered. Not surprisingly, some patients died from an intentional infection of smallpox, but the ones that did survive were indeed immune to future infections.

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Luckily, we have since discovered a less risky method of immunization, but the general concept is similar. The body is exposed to the germs of a virus to elicit an immune response, which is a fight from the immune system to attack the organisms, kill them, and protect the body from being infected. If the body is exposed later on to the same virus in its active form, the immune system recognizes it and knows how to fight it off. But instead of using full-force, potent forms of the virus, we now use killed or weakened germs from a virus to provoke an immune response.

Physicians use attenuated (weakened or altered) forms of the virus because they signal the immune system to learn how to fight the disease without hurting the body. The ‘germs’ they use in the vaccination are samples of microbes or proteins that make up the virus.

Through all of the research and discoveries surrounding vaccines, we’ve been able to prevent a long list of diseases, such as cervical cancer, measles, hepatitis B, whooping cough, pneumonia, mumps, and polio.

Recent outbreaks of measles have occurred in the US and Europe in insular communities where groups of people resist vaccination. The CDC confirms 880 cases of measles occurring across the US this year, the greatest number of cases reported since the disease was declared eliminated in 2000.

Historically, the link between outbreaks of diseases and a concentrated lack of vaccinations holds true. Both Britain and Japan developed anti-vaccination trends in the 1970s, mostly caused by skepticism about the whooping cough (pertussis) vaccine. The World Health Organization reports that 100,000 children were infected with whooping cough in Britain and 38 died. In Japan, the number of infected individuals went from 393 cases to 13,000 cases, and the number of deaths went from 0 to 41.

With such a long history, vaccines continue to shape the knowledge we have about our bodies, immune systems, and how easily viruses and bacteria can affect our health.

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• npr.org
• who.int
• historyofvaccines.org
• cdc.gov